Lung-specific loss of the laminin a3 subunit confers resistance to mechanical injury
نویسندگان
چکیده
Daniela Urich, Jessica L. Eisenberg, Kevin J. Hamill, Desire Takawira, Sergio E. Chiarella, Saul Soberanes, Angel Gonzalez, Frank Koentgen, Tomas Manghi, Susan B. Hopkinson, Alexander V. Misharin, Harris Perlman, Gokhan M. Mutlu, G. R. Scott Budinger* and Jonathan C. R. Jones* Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA Department of Cell and Molecular Biology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA Ozgene Pty. Ltd, Bentley 6102, Western Australia, Australia These authors contributed equally to this work Author for correspondence ([email protected])
منابع مشابه
Lung-specific loss of the laminin α3 subunit confers resistance to mechanical injury.
Laminins are heterotrimeric glycoproteins of the extracellular matrix that are secreted by epithelial cells and which are crucial for the normal structure and function of the basement membrane. We have generated a mouse harboring a conditional knockout of α3 laminin (Lama3(fl/fl)), one of the main laminin subunits in the lung basement membrane. At 60 days after intratracheal treatment of adult ...
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